NANOTECHNOLOGY FOR TARGETED TREATMENTS: THE IMPACT OF LIFESTYLE, AGE, AND GENDER ON EFFICACY IMPROVEMENTS IN DEGENERATIVE DISEASES

Abstract

Since nanotechnology could be a revolutionary field in the fight against diseases, this article focuses on advances in treating degenerative diseases by targeting them with nanomedicine approaches. The idea behind this technology is to direct the effect of drugs where it is necessary by designing nanoparticles that will deliver the drug to a very definite place, thus improving the efficacy of treatment as well as reducing side effects.' Nevertheless, the effectiveness of these nanomedicines is intrinsically linked to personal parameters such as lifestyle, age, and sex. Lifestyle factors — including what we eat, whether we exercise, and whether we smoke — play a major role in the progression of degenerative diseases and the body’s response to nanomedicines. For instance, a diet rich in antioxidants may potentiate these treatments, but smoking may impair their efficacy. Environmental changes in the body that occur as a person ages, such as metabolic and immune functions, may also affect how nanoparticles distribute throughout the body and their functions. In addition, gender-specific variations between body composition and hormone levels can influence responses to nanomedicines, indicating that treatment is needed according to gender. This work investigates how these human parameters— lifestyle, age and gender—interfere with nanotechnology-based therapies for degenerative diseases. Learning about these interactions opens new doors for developing more personalized therapeutic strategies, and with them, we can ensure that nanomedicines are optimized for patient-specific applications.